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USMLE Step 2 is a one-day (8 hours) exam. Similar to the Step 1, the test items are divided into blocks, and test item formats vary within each block, with the total number of exam questions equaling to 355.

USMLE Step 3 is open to candidates who already hold their USMLE Step 1 and Step 2 certificates. Step 3 is a two-day exam that assesses whether candidates are able apply medical knowledge and understanding of biomedical and clinical science essential to unsupervised medical practice. This is the final USMLE exam which leads to the license to practice medicine without supervision - the ultimate goal of medical students and professionals willing to practice medicine in the United States. Step 3 represents the final assessment of physicians assuming independent responsibility for delivering general medical care.

Reference: http://www.usmle.org/step-1/#question-formats

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USMLE USMLE Exam Syllabus Topics:

SectionObjectives
Central and Peripheral Nervous Systems- Neurologic Disorders
  • 1. Neurologic Diseases
  • 2. Neuroanatomy
  • 3. Neuropathology
Multisystem Processes and Disorders- Systemic Conditions
  • 1. Infectious Diseases
  • 2. Neoplasia
  • 3. Nutrition
Respiratory System- Pulmonary Medicine
  • 1. Airway Disorders
  • 2. Lung Diseases
Reproductive System- Male and Female Reproductive Health
  • 1. Reproductive Physiology
  • 2. Reproductive Disorders
Hematopoietic and Lymphoreticular Systems- Blood and Immune Disorders
  • 1. Anemias
  • 2. Leukemias and Lymphomas
  • 3. Coagulation Disorders
Human Development- Growth and Development
  • 1. Embryology
  • 2. Developmental Abnormalities
Musculoskeletal System- Bones, Joints, and Muscles
  • 1. Rheumatologic Diseases
  • 2. Orthopedic Disorders
Renal and Urinary System- Kidney and Urinary Disorders
  • 1. Renal Pathology
  • 2. Renal Physiology
Endocrine System- Hormonal Regulation and Disease
  • 1. Pituitary Disorders
  • 2. Thyroid Disorders
  • 3. Adrenal Disorders
Skin and Related Connective Tissue- Dermatologic Conditions
  • 1. Inflammatory Skin Disorders
  • 2. Skin Neoplasms
General Principles- Foundational Medical Sciences
  • 1. Biochemistry
  • 2. Physiology
  • 3. Pharmacology
  • 4. Pathology
  • 5. Immunology
  • 6. Microbiology
  • 7. Behavioral Sciences
  • 8. Genetics
Gastrointestinal System- Digestive System Disorders
  • 1. Liver Disease
  • 2. Gastrointestinal Pathology
Cardiovascular System- Cardiac and Vascular Disorders
  • 1. Heart Disease
  • 2. Vascular Pathology

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